Rabies virus nucleoprotein (N protein) encapsidates genomic RNA of the virus and forms the viral ribonucleoprotein complex. These N proteins represent highly organized structures which activate proliferation of B cells and production antibodies against the N protein. In addition to the B cell, the rabies virus N protein has been shown to induce potent T helper cell responses resulting in a long...

introduction: the most common mode of rabies virus transmission is through a bite wound or contact of broken skin with saliva of a rabid animal. various other routes of virus transmission include exposure of mucous membranes (i.e. eyes, nose, and mouth) to infected saliva of a rabid animal, aerosol transmission, and corneal transplantation. laboratory workers during work with rabies virus and v...

conclusions the rabies virus np could be extracted and purified in an appropriate amount from infected cell culture. the results of sds-page analysis showed that the intact rabies virus np had been purified properly and thus could be used for further steps to produce the specific diagnostic rabies conjugate. results the volume of the lysate was 15 ml and it became 2.5 ml after purification, wit...

Introduction: The most common mode of rabies virus transmission is through a bite wound or contact of broken skin with saliva of a rabid animal. Various other routes of virus transmission include exposure of mucous membranes (i.e. eyes, nose, and mouth) to infected saliva of a rabid animal, aerosol transmission, and corneal transplantation. Laboratory workers during work with rabies virus and v...

Background: Rabies virus is a neurotropic virus that causes fatal, but, a preventable disease in mammals. Administration of rabies immunoglobulin (RIG) is essential for the post-exposure of the prophylaxis to prevent the disease. However, replacement of polyclonal RIGs with alternative monoclonal antibodies (MAbs) that are capable of neutralizing rabies virus has been recommend...

rabies is a fatal neurological disease and a persistent global problem. it is spread primarily by domestic dogs but other canid, viverrid (skunks and raccoons) and chiropteran species are considered as the most efficient vectors of the disease. since dogs are the main perpetuator of rabies, special attention has to be given to bring all the dogs including unauthorized stray dogs under immunizat...

conclusions the results of this work demonstrated that the subcellular distribution of pfdn1 was altered in the rabv-infected n2a cells and colocalized with the n protein of rabv in the nbl structures. results confocal microscopy showed that pfdn1 was colocalized with the n protein of rabv in the infected n2a cells and was mainly recruited to the characteristic negri-body-like (nbl) structures ...

introduction rabies is an acute fatal viral disease that is generally transmitted from animals to humans following wild and domestic animal bites. the rabies virus enters the body from the area where the individual is bitten, and then the virus moves towards the brain and involves the nerves. case presentation during the years 2001-2011, there have been 73 reported rabies cases. about 50,000 re...

BACKGROUND The pathogenesis of rabies is associated with the inability to deliver immune effectors across the blood-brain barrier and to clear virulent rabies virus from CNS tissues. However, the mechanisms that facilitate immune effector entry into CNS tissues are induced by infection with attenuated rabies virus. METHODOLOGY/PRINCIPAL FINDINGS Infection of normal mice with attenuated rabies...